BDBM448384 7-[(6-{6,6-Difluoro-3-azabicyclo[3.1.0]hexan-3-yl}-::US10695334, Example 13

SMILES Cc1n[nH]c2[C@@H](CCc12)NC(=O)c1cn(Cc2ccc(nc2C)N2CC3C(C2)C3(F)F)c2ncncc12

InChI Key

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 448384   

TargetThymidine kinase, cytosolic(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448384(7-[(6-{6,6-Difluoro-3-azabicyclo[3.1.0]hexan-3-yl}...)
Affinity DataIC50: >1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent